Figure 3. Immunohistochemical staining of brain tissue.

A, a brain section (hippocampus) of an 85-year-old female AD patient (NBB 1999-030) was stained with mouse anti-cyclo[Aβ(22–28)-YNGK′] serum and (B) co-stained with an antibody against APP (6E10). The neuropathological diagnosis of the is patient is Braak stage for neurofibrillary tangles 6 and for amyloid B [43]. C, immunostaining of a plaque-loaded cortex of a 9 month old APPswe/PS1dE9 transgenic mouse.