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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Exp Gerontol. 2010 Nov 25;46(5):349–354. doi: 10.1016/j.exger.2010.11.003

Figure 1. Physiologic consequences of JNK signaling in Drosophila.

Figure 1

The Drosophila JNK signaling pathways consists of a single JNK (Basket), two JNKKs (Hemipterous and dMKK4) and a number of JNKKKs (including MLK: Mixed Lineage Protein Kinase 2/Slipper; ASK1: Apoptotic signal-regulating Kinase 1; TAK1: TGF- Activated Kinase 1; MEKK1: MEK Kinase1). The kinase cascade is activated by a variety of stressful insults, results in activation of the transcription factors AP-1 (Jun/Fos heterodimers) and Foxo, and causes a variety of tissue-specific and context-specific cellular responses. The JNK phosphatase Puckered (Puc) is a target gene of AP-1 and limits JNK activity in a negative feedback loop. Selected genes that are transcriptionally regulated in response to JNK activation, and that mediate specific physiologic consequences of JNK activation, are listed in green.