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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Exp Gerontol. 2010 Nov 25;46(5):349–354. doi: 10.1016/j.exger.2010.11.003

Figure 2. Endocrine interactions mediating JNK – IIS antagonism.

Figure 2

JNK negatively regulates insulin signal transduction cell-autonomously in adipose and peripheral tissues, represses the expression of dilp2 in mNSCs, and promotes expression of the lipocalin NLaz in adipose tissue. NLaz inhibits IIS activity in the periphery. Based on studies in vertebrates, inflammatory cytokines (including Upd1-3) are likely to further influence the interaction between JNK and IIS in flies.