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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Nat Chem Biol. 2011 Mar 27;7(5):278–284. doi: 10.1038/nchembio.545

Figure 6.

Figure 6

Mode of regulation of PTHR signaling by retromer and arrestin. PTH-activated PTHR (green) generating cAMP (grey) by activation of adenyly cyclases internalizes to endosomes in a process that involves binding of β-arrestin (red). Activated PTHR is then maintained in the early endosome bulk compartment by arrestin binding, where arrestin-mediated activation of ERK1/2 signaling causes inhibition of phosphodiesterases and permits sustained cAMP signaling. Binding of PTHR and retromer (blue) causes sorting of the receptor to retrograde trafficking domains. Generation of cAMP is stopped after either retromer binding in the retrograde domain or after retromer-mediated traffic to the Golgi.