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Data are expressed as mean OD ± SD. Blockade of LTβR in Chow mice with LTβR-Ig fusion protein significantly reduced the non-canonical products of p52 (0.51±0.16 vs 0.78±0.26, p<0.01) and Rel B (0.11±0.03 vs 0.16±0.04, p<0.01) to PN levels but had no effect on the inflammatory pathway products of p50 and p65 compared with Chow. As in experiment 1, PN reduced all NF-κB pathway proteins.
