Table 1.
Murine protein | Human ortholog | Description | Ratioa APAP/CON |
---|---|---|---|
Cyp1a2 | CYP1A2 | Cytochrome P450 1A2 | 0.321 |
Cyp2a5 | CYP2A6 | Cytochrome P450 2A5 | N.D.b |
Cyp2c54 | CYP2C19 | Cytochrome P450 2C54 | 0.167 |
Cyp2e1 | CYP2E1 | Cytochrome P450 2E1 | 0.287 |
Cyp3a11 | CYP3A4 | Cytochrome P450 3A11 | 0.295 |
Cyp2d9 | - | Cytochrome P450, family 2, subfamily d, polypeptide 9 | 0.200 |
Mgst1 | MGST1 | Microsomal glutathione S-transferase 1 | 0.617 |
Ratio of APAP-induced spectral counts over control spectral counts as described in reference 56; ratios greater than 1 represent upregulation, whereas ratios less than 1 represent downregulation.
Spectral count ratio could not be determined because no spectra were identified in APAP treatment.