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. Author manuscript; available in PMC: 2012 Apr 18.
Published in final edited form as: Chem Res Toxicol. 2011 Feb 18;24(4):549–558. doi: 10.1021/tx1004198

Table 1.

Differentially regulated mitochondrial proteins identified experimentally in the drug metabolism KEGG pathway following 6 h APAP treatment compared to control in vivo.

Murine protein Human ortholog Description Ratioa APAP/CON
Cyp1a2 CYP1A2 Cytochrome P450 1A2 0.321
Cyp2a5 CYP2A6 Cytochrome P450 2A5 N.D.b
Cyp2c54 CYP2C19 Cytochrome P450 2C54 0.167
Cyp2e1 CYP2E1 Cytochrome P450 2E1 0.287
Cyp3a11 CYP3A4 Cytochrome P450 3A11 0.295
Cyp2d9 - Cytochrome P450, family 2, subfamily d, polypeptide 9 0.200
Mgst1 MGST1 Microsomal glutathione S-transferase 1 0.617
a

Ratio of APAP-induced spectral counts over control spectral counts as described in reference 56; ratios greater than 1 represent upregulation, whereas ratios less than 1 represent downregulation.

b

Spectral count ratio could not be determined because no spectra were identified in APAP treatment.