. Author manuscript; available in PMC: 2012 Apr 18.

Published in final edited form as: Chem Res Toxicol. 2011 Feb 18;24(4):549–558. doi: 10.1021/tx1004198

Table 3.

Significantly altered proteins within the electron transport chain following APAP treatment.

Protein	Complex	2 h APAP/CON Ratio^a		6 h APAP/CON Ratio^a
Protein	Complex	C57BL/6	TAMH	C57BL/6	TAMH
NADH dehydrogenase	I	1.7	1.6	1.8	1.3
Succinate dehydrogenase	II	1.0	N.D.^b	2.2	N.D.^b
Cytochrome b-c1 complex	III	2.6	1.0	4.3	1.6
Cytochrome c oxidase	IV	1.1	2.4	2.5	1.1
ATP synthase	V	1.5	1.4	1.5	1.2

Ratio of APAP-induced spectral counts over control spectral counts as described in reference ⁵⁶; ratios greater than 1 represent upregulation, whereas ratios less than 1 represent downregulation

Spectral count ratio could not be determined because no spectra were identified as significantly different among treatment groups.