Table 4.
Differential expression of protein levels associated with APAP treatment in C57BL/6 mouse liver and TAMH cells, and their comparison to protein expression changes that have been previously reported in the literature.
| Symbol | Description | 2 h, 300 mg/kg, C57BL/6 | 2 h, 2 mM, TAMH | 2 h, 150mg/kg, CD-1 a | 2 h, 500mg/kg, CD-1 a | 6 h, 300 mg/kg, C57BL/6 | 6 h, 2 mM, TAMH | 6 h, 300 mg/kg, C57BL/6 b | 6 h, 300 mg/kg, SJL b |
|---|---|---|---|---|---|---|---|---|---|
| Acaa2 | 3-ketoacyl-CoA thiolase | 1.3 | 0.7 | 0.7 | 0.6 | 1.4 | - | - | - |
| Aldh2 | Aldehyde dehydrogenasec | 1.8 | - | 0.7 | 0.6 | 1.8 | - | - | - |
| Atp5a1 | Atp5a1 ATP synthase subunit alpha | - | - | 1.0 | 0.5 | 1.4 | - | - | - |
| Atp5b | Atp5b ATP synthase subunit beta | 1.4 | - | 1.0 | 0.8 | 1.4 | - | - | - |
| Cps1 | Carbamoyl-phosphate synthase [ammonia]c | 1.1 | - | - | - | 1.3 | - | - | - |
| Cyp3a11 | Cyp3a11 Cytochrome P450 3A11 | - | - | - | - | 0.3 | - | 0.4 | 0.9 |
| Glud1 | Glutamate dehydrogenase 1c | 2.1 | 0.9 | - | - | 1.3 | - | - | - |
| Hspa9 | Stress-70 proteinc | - | 1.2 | 2.4 | 3.3 | - | - | - | - |
| Prd | Thioredoxin-dependent peroxide reductasec | - | 3.9 | 0.4 | 0.8 | - | 2.7 | - | - |
| Sod2 | Superoxide dismutase [Mn]c | - | - | - | - | 2.2 | - | - | - |