Table 3. Between-Groups Comparison.

ROI	Group
	Measurea	MDMA (mean±SD)	Non-MDMA (mean±SD)	p-Value*	High-MDMA (mean±SD)	p-Value**	Low-MDMA (mean±SD)	p-Value***
LGN	Signal intensity	0.014±0.030	0.031±0.045	0.221	0.033±0.016	0.713	−0.006±0.027	0.015
BA 17	Signal intensity	0.121±0.104	0.132±0.124	0.989	0.170±0.114	0.248	0.068±0.022	0.248
	Spatial extent	32.210±32.48	24.53±25.63	0.478	51.899±33.491	0.031b	12.529±15.633	0.328
BA 18	Signal intensity	0.089±0.070	0.091±0.085	0.904	0.1204±0.082	0.475	0.057±0.038	0.350
	Spatial extent	26.685±29.533	17.863±20.200	0.529	43.227±33.174	0.049	10.143±11.520	0.373

Abbreviations: BA, Brodmann Area; LGN, lateral geniculate nucleus; ROI, region of interest; SD, standard deviation of the mean.

^aData are presented as mean percent signal intensity or spatial extent (activated voxels) in an ROI. Spatial extent data is not reported for LGN because no activated voxels were detected in LGN using corrected statistical thresholds. Between-group comparisons were performed using Mann–Whitney U-test for non-parametric data.

^bBolded text, significant at p<0.05.

^*p-Value represents comparison of entire MDMA group to non-MDMA control group.

^**p-Value represents comparison of high-exposure MDMA subgroup to non-MDMA control group.

^***p-Value represents comparison of low-exposure MDMA subgroup to non-MDMA control group.