Family history |
One 1st degree relative |
1.7-2.0 |
Pharoah et al., 2000 29; Collaborative Group on Hormonal Factors in Breast Cancer, 2001 30
|
|
Two 1st degree relatives |
2.0 |
Collaborative Group on Hormonal Factors in Breast Cancer, 2001 30
|
|
Three or more 1st degree relatives |
3.9 |
Collaborative Group on Hormonal Factors in Breast Cancer, 2001 30
|
Inherited genetic mutation |
BRCA1 or BRCA2 |
5.7 |
Schwab et al., 2002 31
|
Histology of breast biopsy |
Personal history of breast cancer |
2.0-4.0 |
Feig et al., 1998 32
|
|
Atypical Hyperplasia |
4.0 |
Feig et al., 1998 32
|
|
LCIS |
5.9-12.0 |
Feig et al., 1998 32
|
Other high-risk factors |
Female; Age (65+ vs. <65 years); High breast tissue density; |
> 4.0 |
Breast Cancer Facts & Figures 2009-2010 3
|
|
High-dose chest radiation; High bone density post-menopausal |
2.1 - 4.0 |
Breast Cancer Facts & Figures 2009-2010 3
|
|
Personal history of endometrial or ovarian cancer; Alcohol consumption; High socioeconomic status; Ashkenazi Jewish heritage |
1.1-2.0 |
Breast Cancer Facts & Figures 2009-2010 3
|
Factors affecting circulating hormones |
Age > 30 years at first full-term pregnancy; Early menarche (Age <12); Late menopause (Age >55); No full-term pregnancies; Never breastfed a child; Recent oral contraceptive use; Recent and long-term use of estrogen and progestin; Obesity (postmenopausal) |
1.1-2.0 |
Breast Cancer Facts & Figures 2009-2010 3
|