Table 1.
Molecular Weight and Polydispersity of Poly(amine-co-esters) and Characterization of Poly(amine-co-ester)/pLucDNANanoparticles
| Substrates | Isolated Polymer | Properties of polyplexc | |||||
|---|---|---|---|---|---|---|---|
| Diethyl Diester | Diol | Namea | Mwb | Mw/Mnb | Mean Particle Diameters (nm) | Zeta Potential (mV) | |
| In NaAc | In Hepes | ||||||
| Succinate | N-Methyldiethanolamine | PMSN | 29500 | 2.3 | 620 | 8.7 | −5.7 |
| Adipate | N-Methyldiethanolamine | PMAP | 29600 | 2.3 | >1000 | 13.3 | −20.6 |
| Suberate | N-Methyldiethanolamine | PMSR | 30300 | 2.4 | >1000 | 20.7 | −23.4 |
| Sebacate | N-Methyldiethanolamine | PMSC | 31800 | 2.3 | 69 | 35.4 | −31.4 |
| Dodecanedioate | N-Methyldiethanolamine | PMDO | 41200 | 2.4 | 107 | 22.0 | −26.2 |
| Sebacate | N-Ethyldiethanolamine | PESC | 29900 | 2.3 | 41 | 26.7 | −23.9 |
| Sebacate | N-n-Butyldiethanolamine | PBnSC | 36000 | 2.2 | 880 | 10.4 | −16.9 |
| Sebacate | N-t-Butyldiethanolamine | PBtSC | 44500 | 2.0 | >1000 | 14.6 | −15.3 |
| Sebacate | N-Phenyldiethanolamine | PPSC | 44200 | 2.2 | 724 | 11.3 | −9.6 |
Abbreviations name of the polymers.
Molecular weight and polydispersity are cited from our previous work 44.
The polyplex nanoparticles were formed at polymer/DNA weight ratio of 100.