Table 4. Diagnostic schemes for AI-ALF vs. clinical and laboratory characteristics of autoimmune hepatitis and acute liver failure.
Overall survival refers to cumulative rates at 21 days from admission. Simplified Diagnostic Criteria for AIH pertain to a composite score based upon histology, presence of autoantibodies, serum globulin concentrations, and the absence of hepatitis viral markers, as described by Hennes, et al (4).
| Clinical Characteristic | Histological Diagnosis Probable AI-ALF | Histological Diagnosis Probable AI-ALF and ANA ± ASMA | Simplified Diagnostic Criteria for AIH ≥ 6 Points | |||
|---|---|---|---|---|---|---|
| Present N = 42 | Absent N = 30 | Present N = 30 | Absent N = 42 | Present N = 29 | Absent N = 43 | |
| Female Gender (%) | 62 | 53 | 73* | 48 | 69 | 51 |
| Jaundice-to-coma (days) | 22 ± 3* | 11 ± 3 | 21 ± 3 | 14 ± 3 | 22 ± 3* | 13 ± 3 |
| Admission INR | 3.1 ± 0.3 | 3.4 ± 0.4 | 2.9 ± 0.4 | 3.5 ± 0.3 | 3.1 ± 0.4 | 3.3 ± 0.3 |
| Peak Creatinine (mg/dl) | 2.1 ± 0.3* | 3.2 ± 0.4 | 2.2 ± 0.3 | 2.7 ± 0.3 | 2.2 ± 0.4 | 2.7 ± 0.3 |
| Admission Bilirubin (mg/dl) | 25.4 ± 1.8 | 27.8 ± 2.1 | 24.1 ± 2.1 | 24.7 ± 2.8 | 25.3 ± 2.1 | 24.3 ± 2.7 |
| ALT on Admission (IU/L) | 921 ± 175* | 1456 ± 207 | 851 ± 210* | 1393 ± 181 | 936 ± 214 | 1284 ± 176 |
| Admission Alkaline Phosphatase (IU/L) | 192 ± 19 | 224 ± 23 | 190 ± 23 | 221 ± 20 | 196 ± 24 | 211 ± 20 |
| Admission Globulins (g/dL) | 3.7 ± 0.2* | 3.0 ± 0.2 | 3.9 ± 0.2** | 3.0 ± 0.2 | 4.3 ± 0.2† | 2.7 ± 0.2 |
| ANA ± ASMA (%) | 73* | 48 | 100† | 35 | 93† | 42 |
| Overall Survival (%) | 86** | 50 | 87* | 60 | 86* | 61 |
| Hepatitis in Follow-Up (%) | 52 | 17 | 67** | 17 | 60 | 25 |
*
P ≤ 0.05,
**
P < 0.01,
†
P < 0.0001 vs. “absent” group.