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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Neurol Clin. 2011 May;29(2):257–278. doi: 10.1016/j.ncl.2010.12.009

Figure 1.

Figure 1

Gross and histologic features of MS plaques. (A) Gross examination of the brain at autopsy of a 79 year old with RR-MS. A dorsal view of the corpus callosum after separation of the cerebral hemispheres reveals a hardened, discolored area within the body of the corpus callosum (arrow). Photo courtesy of Dr. Robert Schmidt. (B) Acute MS plaque stained with Hematoxylin and Eosin revealing hypercellularity due to the perivascular and parenchymal infiltration of leukocytes. (C) Luxol fast blue/periodic acid–Schiff (LFB-PAS) stained section of a plaque margin reveals a blurred but discrete edge (arrows). (D) Inactive plaque demonstrating borders that are distinct and devoid of inflammation (E) CD3 + lymphocytes clustering in a perivascular cuff within an active lesion area (F) Foamy macrophages characterized by fragments of myelin (arrow) engulfed by macrophages are identified using LFB-PAS at a plaque margin. Images in B-F used with permission; 98 (copyright Elsevier, 2010).