Figure 8.

Pathways modulated by C1q in neurons. C1q rapidly upregulates the expression of genes associated with membrane and cytoskeleton function, including neurite outgrowth (stx3) and cholesterol and lipid metabolism, suggesting that C1q may modulate a complex system involved in membrane stabilization and growth of neurites. In addition, C1q increases the phosphorylation of CREB and the expression of C/EBP-δ, which both stimulate NGF production, as well as their nuclear translocation, while downregulating the expression of miRNAs predicted to target several neurotrophic factors, including NGF, NT-3, and NTN1. Yellow, Upregulated; blue, downregulated.