Table 1.

SPECT and PET ABC substrates (s) and inhibitors (i) and their relationships to genes

Imaging modality	Radiopharmaceuticals	ABC transporter	Gene symbol
SPECT	[99mTc]MIBI (s)	P-gp	ABCB1 (mdr1)
		MRP1,2 BCRP	ABCC1,2
			ABCG2
	[99mTc]Tetrofosmin (s)	P-gp	ABCB1 (mdr1)
		MRP1,2	ABCC1,2
	[99mTc]HIDA (s)	MRP1,2	ABCC1,2
	[67Ga]3-ethoxy- ENBDMPI (s)	P-gp	ABCB1 (mdr1)
		MRP1	ABCC1
PET and microPET (µ)	[94mTc]MIBI (s, µ)	P-gp	ABCB1 (mdr1)
		MRP1,2	ABCC1,2
		BCRP	ABCG2
	[11C]Colchicines (i, µ)	P-gp	ABCB1 (mdr1)
	[11C]Verapamil (i)	P-gp	ABCB1 (mdr1)
	[11C]Loperamide (i)	P-gp	ABCB1 (mdr1)
	[11C]Paclitaxel (i, µ)	P-gp	ABCB1 (mdr1)
	[11C]Daunorubicin (i, µ)	P-gp	ABCB1 (mdr1)
	4-[18F]Fluoropaclitaxel (i, µ)	P-gp	ABCB1 (mdr1)
	[11C]Tariquidar (i, µ)	P-gp	ABCB1 (mdr1)
	[68Ga]3-ethoxy-ENBDMPI (s)	P-gp, MRP1	ABCB1 (mdr1);ABCC1
	N-[11C]Acetyl leukotriene E4 (s)	MRP 2	ABCC2