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. Author manuscript; available in PMC: 2012 Apr 15.
Published in final edited form as: Biol Psychiatry. 2011 Feb 26;69(8):780–787. doi: 10.1016/j.biopsych.2010.12.029

Figure 5.

Figure 5

The selective 5-HT1B agonist CP-94,253 (1.0 mg/kg, i.p.) reduces conditioned fear only when paired with presentation of the conditioned stimulus. A, rats trained in contextually conditioned fear (n=13 per group) were assigned to one of two experiments in which drug was paired with reexposure to fear context or unpaired. B, CP-94,253 paired with context re-exposure reduced measures of fear on the day of injection (Day 1) and during a subsequent, drug-free trial (Day 2). C, CP-94,253 given in a neutral environment (Day 1) did not affect expression conditioned fear 24 h later (Day 2). Graphs depict mean +SEM percent of observations that rats spent freezing during tests of conditioned fear. * p<0.05 vs. saline.