Figure 5.

γδ T cells participate in the afferent and efferent arms of allergic conjunctivitis. CD4⁺ T cells isolated from SRW-sensitized donors were adoptively transferred into naive recipients. (A) Clinical scores of allergic conjunctivitis in naive WT recipients that received CD4⁺ T cells from either WT donors (●) or TCR-δ^−/− donors (○) or that were sensitized with SRW pollen. (B) Eosinophillic infiltration into the conjunctivae of WT recipients of CD4⁺ T cells from SRW-sensitized TCR-δ^−/− or WT donors. (C) Clinical scores of allergic conjunctivitis in naive WT (●) or TCR-δ^−/− (○) recipients of CD4⁺ T cells from WT donors that were sensitized with SRW pollen. (D) Eosinophillic infiltration into the conjunctivae of TCR-δ^−/− and WT C57BL/6 mice that received CD4⁺ T cells from WT C57BL/6 mice that were sensitized with SRW pollen (n = 10). Graph is representative of two independent replicate experiments. *P < 0.05.