TABLE 3.
Multivariable logistic regression analysis of factors predicting Gleason sum upgrading and downgrading from biopsy to radical prostatectomy specimen among men in the SEARCH Database
Odds Ratio | 95% CI | P Value | |
---|---|---|---|
Predictors of upgrading | |||
Serum PSA | 1.91 | 1.48 – 2.47 | <0.001 |
Biopsy Gleason sum (3+4 vs. 2–6) | 0.51 | 0.34 – 0.75 | 0.001 |
No. of biopsy cores with cancer | 1.13 | 1.04 – 1.22 | 0.002 |
Body mass index (≥30 vs. <25 kg/m2) | 1.89 | 1.24 – 2.87 | 0.003 |
No. of biopsy cores obtained (≥8 vs. <8) | 0.62 | 0.43 – 0.89 | 0.01 |
Year of surgery | 1.07 | 1.00 – 1.14 | 0.06 |
Body mass index (≥25 – <30 vs. <25 kg/m2) | 1.44 | 0.99 – 2.11 | 0.06 |
Predictors of downgrading | |||
No. of biopsy cores obtained (≥8 vs. <8) | 3.16 | 1.63 – 6.14 | 0.001 |
Serum PSA | 0.53 | 0.34 – 0.81 | 0.003 |
Year of surgery | 0.88 | 0.80 – 0.98 | 0.02 |