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. Author manuscript; available in PMC: 2011 Apr 20.
Published in final edited form as: Urology. 2007 Mar;69(3):495–499. doi: 10.1016/j.urology.2006.10.036

TABLE 3.

Multivariable logistic regression analysis of factors predicting Gleason sum upgrading and downgrading from biopsy to radical prostatectomy specimen among men in the SEARCH Database

Odds Ratio 95% CI P Value
Predictors of upgrading
 Serum PSA 1.91 1.48 – 2.47 <0.001
 Biopsy Gleason sum (3+4 vs. 2–6) 0.51 0.34 – 0.75 0.001
 No. of biopsy cores with cancer 1.13 1.04 – 1.22 0.002
 Body mass index (≥30 vs. <25 kg/m2) 1.89 1.24 – 2.87 0.003
 No. of biopsy cores obtained (≥8 vs. <8) 0.62 0.43 – 0.89 0.01
 Year of surgery 1.07 1.00 – 1.14 0.06
 Body mass index (≥25 – <30 vs. <25 kg/m2) 1.44 0.99 – 2.11 0.06
Predictors of downgrading
 No. of biopsy cores obtained (≥8 vs. <8) 3.16 1.63 – 6.14 0.001
 Serum PSA 0.53 0.34 – 0.81 0.003
 Year of surgery 0.88 0.80 – 0.98 0.02