Table 2.
p53 expression in relation to main tumor characteristics and treatment response
| p53 expression | ||||
|---|---|---|---|---|
| Total | Low | High | p value | |
| Age | ||||
| < 55 yrs | 18 | 13 | 5 | n.s. |
| ≥55 yrs | 18 | 12 | 6 | |
| ER expression | ||||
| Negative | 14 | 8 | 6 | n.s. |
| Positive | 22 | 17 | 5 | |
| PgR expression | ||||
| Negative | 13 | 9 | 4 | n.s. |
| Positive | 23 | 16 | 7 | |
| Grading# | ||||
| G2 | 21 | 17 | 4 | n.s. |
| G3 | 15 | 8 | 7 | |
| Stage*° | ||||
| I-IIA | 17 | 15 | 2 | 0.02 |
| IIB-III | 16 | 7 | 9 | |
| HER2 | ||||
| Negative" | 27 | 21 | 6 | n.s. |
| Positive" | 9 | 4 | 5 | |
| Ki67 | ||||
| Negative | 22 | 15 | 7 | n.s. |
| Positive | 14 | 10 | 4 | |
| Treatment response | ||||
| CR+PR | 15 | 11 | 4 | n.s. |
| SD+PD | 21 | 14 | 7 | |
n.s. = not significant; CR = complete response; PR = partial response; SD = stable disease; PD = disease progression. #According to Elston and Ellis classification (Ref. 31). *According to UICC-TNM classification of malignant tumours, sixth edition 2002 (Ref. 30). °At initial diagnosis time. "IHC 0,1+ and 2+ FISH negative were regarded as negative while IHC 3+ or 2+ FISH positive were regarded as positive.