Table 3.
HER2 expression in relation to main tumor cheracteristics and treatment response
| HER2 expression" | ||||
|---|---|---|---|---|
| Total | Low | High | p value | |
| Age | ||||
| < 55 yrs | 18 | 13 | 5 | n.s. |
| ≥55 yrs | 18 | 14 | 4 | |
| ER expression | ||||
| Negative | 14 | 10 | 4 | n.s. |
| Positive | 22 | 17 | 5 | |
| PgR expression | ||||
| Negative | 13 | 9 | 4 | n.s. |
| Positive | 23 | 18 | 5 | |
| Grading# | ||||
| G2 | 21 | 18 | 3 | 0.05 |
| G3 | 15 | 8 | 7 | |
| Stage*° | ||||
| I-IIA | 17 | 16 | 1 | 0.003 |
| IIB-III | 16 | 8 | 8 | |
| Ki67 | ||||
| Negative | 22 | 18 | 4 | n.s. |
| Positive | 14 | 9 | 5 | |
| Treatment response | ||||
| CR+PR | 15 | 9 | 6 | 0.046 |
| SD+PD | 21 | 18 | 3 | |
"IHC 0, 1+ and 2+ FISH negative were regarded as negative while IHC 3+ or 2+ FISH positive were regarded as positive. #According to Elston and Ellis classification (see text for complete reference). *According to UICC-TNM classification of malignant tumours, sixth edition 2002. °At initial diagnosis time. n.s. = not significant; CR = complete response; PR = partial response; SD = stable disease; PD = disease progression.