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. 2011 Apr 8;11:34. doi: 10.1186/1471-230X-11-34

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Copyright ©2011 Rath et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Expression of MMP-7 in UC patients (n = 49). mRNA results were determined by RT-PCR. MMP-7 gene expression was not significantly different in UC patients with intestinal MAP detection and those without (p = 0.318) and did not differ between patients receiving an anti-inflammatory therapy (AIT) and those without AIT (p = 0.094). Further stratification into subgroups of patients receiving 5-amino salicylic acid (5-ASA) and its derivatives, corticosteroids or immunomodulators (azathioprine and infliximab) revealed no significant differences in MMP-7 expression between patients treated with the respective substance and those not receiving the respective agent. Note, that some patients received more than one substance class and therefore appear in more than one subgroup.