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. 2011 Apr 20;6(4):e19102. doi: 10.1371/journal.pone.0019102

Figure 2. MUC1-CD induces precocious development of mammary glands during prepuberty and early puberty.

Figure 2

(A) Mammary glands from a MUC1-CD transgenic female mouse (right) and a wild-type littermate (left). (B) Comparison of the weight/body ratio of the fourth mammary glands between MUC1-CD transgenic mice (n = 4) and wild-type littermates (n = 4). (C) Carmine alum staining of whole mounts of inguinal mammary glands from a wild-type female (left) and transgenic female (right) in 2-wk-old virgins (upper) and 5-wk-old virgins (lower). As indicated by the arrows, in 2-wk-old virgins, the precocious development of mammary epithelial ducts was apparently observed in transgenic mice (upper right) compared to wild-type littermates (upper left). (D) Quantification of the number of terminal end buds (TEBs) and end buds (EBs) in MUC1-CD transgenic mice (n = 3) and wild-type littermates (n = 3) at 5 wks of age. *P<0.05; **P<0.01.