Table 2.
Univariable Hazard Ratio of Fertility among Female Survivors of Childhood Cancer Who Were Not Surgically Sterile
| HR | 95% CI | p-value | |
|---|---|---|---|
| Race/Ethnicity | |||
| Non-Hispanic White | 1.00 | ||
| Hispanic | 1.46 | 1.14, 1.86 | 0.002 |
| Non-Hispanic Black | 1.00 | 0.79, 1.28 | 0.974 |
| Other | 1.01 | 0.74, 1.38 | 0.933 |
| Smoking Status | |||
| Never smoked | 1.00 | ||
| Current smoker | 1.98 | 1.76, 2.23 | <0.001 |
| Former smoker | 1.53 | 1.35, 1.75 | <0.001 |
| Marital Status | |||
| Never married | 1.00 | ||
| Currently married | 5.46 | 4.66, 6.39 | <0.001 |
| Formerly married | 4.81 | 3.91, 5.93 | <0.001 |
| Education Level | |||
| High School or GED | 1.00 | ||
| No High School or GED | 1.27 | 1.03, 1.57 | 0.027 |
| Some college no bachelor’s degree | 0.83 | 0.72, 0.95 | 0.006 |
| Bachelor’s degree or higher | 0.47 | 0.41, 0.54 | <0.001 |
| Age at Diagnosis in years | |||
| 0–4 | 1.00 | ||
| 5–9 | 0.92 | 0.79, 1.07 | 0.267 |
| 10–14 | 0.99 | 0.86, 1.14 | 0.915 |
| 15–19 | 0.92 | 0.78, 1.08 | 0.301 |
| 20 | 0.99 | 0.70, 1.42 | 0.975 |
| Oophoropexy | |||
| No | 1.00 | ||
| Yes | 0.80 | 0.43, 1.51 | 0.498 |
| Hypothalamic/pituitary Radiation Dose | |||
| 0 | 1.00 | ||
| > 0 to < 1500 cGy | 0.93 | 0.76, 1.14 | 0.481 |
| ≥ 1500 to < 2200 cGy | 0.81 | 0.63, 1.03 | 0.081 |
| ≥ 2200 to < 2700 cGy | 0.67 | 0.55, 0.81 | <0.001 |
| ≥ 2700 cGy | 0.49 | 0.36, 0.67 | <0.001 |
| Alkylating Agent Dose summed Score | |||
| 0 | 1.00 | ||
| 1 | 0.98 | 0.77, 1.25 | 0.855 |
| 2 | 1.07 | 0.87, 1.31 | 0.544 |
| 3 | 0.92 | 0.74, 1.14 | 0.452 |
| 4 | 0.67 | 0.43, 1.02 | 0.062 |
| 5 | 1.33 | 0.88, 2.00 | 0.175 |
| 6 – 11 | 0.75 | 0.45, 1.26 | 0.278 |
| Actinomycin D | |||
| No | 1.00 | ||
| Yes | 1.20 | 1.00, 1.44 | 0.056 |
| BCNU | |||
| No | 1.00 | ||
| Yes | 0.77 | 0.53, 1.12 | 0.172 |
| CCNU | |||
| No | 1.00 | ||
| Yes | 0.48 | 0.25, 0.94 | 0.032 |
| Chlorambucil | |||
| No | 1.00 | ||
| Yes | 0.63 | 0.20, 1.96 | 0.425 |
| Cis-Platinum | |||
| No | 1.00 | ||
| Yes | 1.15 | 0.91, 1.46 | 0.236 |
| Cyclophosphamide | |||
| No | 1.00 | ||
| Yes | 0.99 | 0.86, 1.13 | 0.859 |
| Cytosine arabinoside | |||
| No | 1.00 | ||
| Yes | 0.94 | 0.80, 1.10 | 0.418 |
| Daunorubicin | |||
| No | 1.00 | ||
| Yes | 0.92 | 0.74, 1.15 | 0.486 |
| Doxorubicin | |||
| No | 1.00 | ||
| Yes | 1.07 | 0.93, 1.23 | 0.362 |
| DTIC | |||
| No | 1.00 | ||
| Yes | 0.90 | 0.58, 1.38 | 0.617 |
| Ifosfamide | |||
| No | 1.00 | ||
| Yes | 1.15 | 0.46, 2.85 | 0.762 |
| Melphalan | |||
| No | 1.00 | ||
| Yes | 1.07 | 0.60, 1.91 | 0.815 |
| Nitrogen mustard | |||
| No | 1.00 | ||
| Yes | 0.84 | 0.58, 1.20 | 0.338 |
| Procarbazine | |||
| No | 1.00 | ||
| Yes | 0.94 | 0.71, 1.25 | 0.660 |
| Thiotepa | |||
| No | 1.00 | ||
| Yes | 0.92 | 0.30, 2.86 | 0.885 |
| Vinblastine | |||
| No | 1.00 | ||
| Yes | 1.09 | 0.72, 1.65 | 0.682 |
| Vincristine | |||
| No | 1.00 | ||
| Yes | 1.02 | 0.89, 1.18 | 0.740 |
| VM-26 | |||
| No | 1.00 | ||
| Yes | 0.76 | 0.49, 1.18 | 0.219 |
| VP-16 | |||
| No | 1.00 | ||
| Yes | 1.13 | 0.79, 1.60 | 0.507 |