Table 3.

Multivariable Hazard Ratio of Fertility among Female Survivors of Childhood Cancer Who Were Not Surgically Sterile

	HR*	95% CI	p-value
Race/Ethnicity
Non-Hispanic White	1.00
Hispanic	1.00	0.70, 1.43	0.995
Non-Hispanic Black	2.81	2.01, 3.93	<0.001
Other	1.04	0.66, 1.65	0.857
Smoking Status
Never smoked	1.00
Current smoker	1.61	1.33, 1.95	<0.001
Former smoker	1.15	0.93, 1.42	0.187
Marital Status
Never married	1.00
Currently married	5.98	4.83, 7.41	<0.001
Formerly married	3.70	2.76, 4.97	<0.001
Education
High school/GED	1.00
No High school/GED	1.38	1.02, 1.86	0.037
Some college	0.87	0.71, 1.06	0.164
Bachelor or higher	0.48	0.39, 0.60	<0.001
Age at diagnosis (years)
0 – 4	1.00
5–9	0.76	0.60, 0.97	0.028
10–14	0.83	0.66, 1.05	0.114
15–19	0.63	0.47, 0.84	0.002
20	0.96	0.55, 1.68	0.896
Hypothalamic/pituitary Radiation Dose
0	1.00
> 0 to < 1500 cGy	0.88	0.71, 1.10	0.261
≥ 1500 to < 2200 cGy	1.04	0.79, 1.36	0.793
≥ 2200 to < 2700 cGy	0.67	0.53, 0.84	0.001
≥ 2700 cGy	0.65	0.46, 0.92	0.014
Actinomycin D
No	1.00
Yes	1.18	0.96, 1.44	0.112
VP-16
No	1.00
Yes	1.54	1.06, 2.24	0.023