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Effect size erosion in case-control design is plotted according to varying cohort ages and genetic relative risk of lethality (GRR-L) for myocardial infarction. The median (thick line) and range (box-plot with whiskers) for each GRR-L simulation reflects the ranges of minor allele frequency and genetic relative risk of disease. The top panel assumes 0% ascertainment of lethal cases, while the bottom panel assumes 40% ascertainment of lethal cases.
