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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Circ Cardiovasc Genet. 2011 Feb 15;4(2):179–187. doi: 10.1161/CIRCGENETICS.110.957662

Table 3. Single-marker analysis of decrease in systolic blood presssure (SBP) and norepinephrine plasma concentrations (NE) after dexmedetomidine.

Decrease of systolic BP and NE was assessed as difference between the area under the curve for the respective variables between placebo infusions and dexmedetomidine infusions (ΔAUCSBP and ΔAUCNE, respectively). Uncorrected p-values are from multiple linear regression analyses assuming an additive model of inheritance. Adjusted p-values are after adjustment for the covariates AUCSBP or AUCNE during placebo, respectively, dexmedetomidine plasma concentrations, age, sex, race, and BMI.

ΔAUCSBP, mmHg* hr (mean±SD) ΔAUCNE, pg/mL* hr (mean±SD)
SNP Number of minor alleles P-value Adjusted P-value Number of minor alleles P-value Adjusted P-value
0 1 2 0 1 2
1 rs11195418 −11.0±6.2
n=65		 −10.1±4.1
n=5		 −12.5
n=1		 0.92 0.90 −104.5±76.5
n=65		 −29.1±54.5
n=5		 −66.3
n=1		 0.15 0.72
2 rs1800544 −9.5±5.0
n=23		 −12.3±6.1
n=32		 −11.1±6.3
n=18		 0.26 0.49 −119.2±80.2
n=23		 −86.1±63.6
n=31		 −95.1±88.3
n=18		 0.28 0.12
3 rs2484516 −10.5±5.8
n=64		 −13.6±7.5
n=4		 −25.3
n=1		 0.06* 0.07* −101.3±76.4
n=64		 −99.9±75.1
n=4		 −153.5
n=1		 0.79 0.46
4 rs1800545 −11.4±6.5
n=42		 −10.8±6.4
n=28		 −10.8±4.9
n=3		 0.93 0.13 −106.3±81.2
n=42		 −89.6±71.5
n=27		 −79.3±19.7
n=3		 0.61 0.41
5 rs1800035 −10.8±6.3
n=67		 −15.3±5.5
n=6		 n.a. 0.090 0.18 −97.2±77.8
n=67		 −118.2±52.8
n=6		 n.a. 0.52 0.53
6 rs1800038_ −10.9±6.1
n=67		 −12.8±4.1
n=3		 n.a. 0.58 0.73 −98.4±78.4
n=67		 −127.1±47.7
n=3		 n.a. 0.53 0.99
7 rs34303217 −10.8±6.1
n=69		 −17.1±8.7
n=4		 n.a. 0.051 0.53 −99.4±77.7
n=69		 −91.1±42.2
n=4		 n.a. 0.83 0.81
8 rs553668 −10.1±5.8
n=51		 −12.1±5.8
n=19		 −22.8±7.4
n=3		 0.002 0.028 −104.6±77.1
n=51		 −88.6±69.7
n=19		 −69.3±111.4
n=3		 0.59 0.17
9 rs3750625 −11.5±6.4
n=53		 −9.1±4.6
n=15		 −9.9±6.5
n=2		 0.38 0.052 −100.9±85.6
n=53		 −97.1±47.1
n=15		 −85.9±22.8
n=2		 0.96 0.82
*

The single subject homozygous for the variant allele was grouped with the heterozygotes for statistical analysis.

SNP=single nucleotide polymorphism. n.a.=genotype not represented in cohort.