Table 2.
BDNF, trkB-TK+ and GAD67 mRNA expression
| Group; mean (SD)
|
|||||
|---|---|---|---|---|---|
| Marker; brain region | p value | Schizophrenia | Depression | Bipolar disorder | Control |
| BDNF | |||||
| Dentate gyrus | 0.24 | 196 (38) | 230 (67) | 216 (43) | 223 (20) |
| CA1 | 0.94 | 26 (9) | 28 (12) | 29 (8) | 29 (11) |
| CA3 | 0.35 | 131 (46) | 135 (39) | 117 (62) | 150 (40) |
| CA4* | 0.044 | 64 (25) | 71 (25) | 58 (25) | 87 (28) |
| Subiculum | 0.31 | 24 (6) | 27 (10) | 25 (7) | 29 (7) |
| Entorhinal cortex | |||||
| Layer 1 | 0.08 | 14 (5) | 10 (4) | 11 (4) | 11 (4) |
| Layer 2 | 0.90 | 45 (15) | 40 (7) | 40 (19) | 42 (11) |
| Layer 3 | 0.95 | 24 (8) | 25 (8) | 25 (9) | 24 (5) |
| Layer 5 | 0.97 | 25 (9) | 25 (9) | 24 (10) | 25 (5) |
| Layer 6 | 0.75 | 22 (7) | 24 (7) | 21 (8) | 24 (5) |
| TrkB-TK+ | |||||
| Dentate gyrus | 0.27 | 89 (21) | 100 (28) | 94 (22) | 111 (12) |
| CA1 | 0.63 | 73 (11) | 72 (11) | 75 (14) | 78 (14) |
| CA3 | 0.49 | 95 (17) | 109 (32) | 102 (29) | 115 (21) |
| CA4† | 0.025 | 48 (19) | 63 (19) | 58 (19) | 75 (10) |
| Subiculum | 0.56 | 82 (9) | 90 (23) | 79 (14) | 89 (16) |
| Entorhinal cortex | |||||
| Layer 1 | 0.05 | 58 (22) | 45 (18) | 46 (24) | 72 (20) |
| Layer 2‡ | 0.012 | 100 (29) | 93 (23) | 85 (15) | 118 (17) |
| Layer 3 | 0.48 | 84 (22) | 90 (25) | 89 (29) | 103 (15) |
| Layer 5 | 0.76 | 73 (23) | 78 (24) | 76 (25) | 88 (20) |
| Layer 6 | 0.40 | 56 (7) | 67 (17) | 62 (12) | 70 (15) |
| GAD67 | |||||
| Dentate gyrus§ | 0.034 | 205 (56) | 230 (58) | 235 (54) | 266 (36) |
| CA1 | 0.24 | 20 (12) | 24 (13) | 28 (13) | 32 (13) |
| CA3 | 0.84 | 37 (14) | 35 (16) | 39 (21) | 46 (23) |
| CA4¶ | 0.008 | 21 (16) | 29 (18) | 37 (28) | 52 (25) |
| Subiculum | 0.91 | 53 (33) | 56 (16) | 49 (24) | 63 (17) |
| Entorhinal cortex | 0.34 | 80 (53) | 72 (18) | 84 (43) | 100 (35) |
BDNF = brain-derived neurotrophic factor; CA = cornu ammonis subfield; GAD67 = glatamic acid decarboxylase; SD = standard deviation; trkB-TK+ = tyrosine kinase receptor.
*
Bipolar disorder < normal, p = 0.004.
†
Schizophrenia < normal, p < 0.001.
‡
Major depression < normal, p = 0.006; bipolar disorder < normal, p = 0.002.
§
Schizophrenia < normal, p = 0.004.
¶
Schizophrenia < normal, p < 0.001; major depression < normal, p = 0.005.