. Author manuscript; available in PMC: 2011 Apr 21.

Published in final edited form as: Nat Genet. 2010 Apr 25;42(5):448–453. doi: 10.1038/ng.573

Table 2.

Association of SNPs in 4 chromosomal regions with lung cancer in four populations. Shown are the number of cases and controls (N), the frequencies of the effect allele (see Table 1) in cases and controls, the odds ratio and 95% confidence intervals (OR and 95%CI), the P value for the test of association (P). The results for Peripheral Arterial Disease are shown in Supplementary Table 4.

	N		Freq

Population	case	control	case	control	OR (95% CI)	P
rs6474412-T, chromosome 8p11
Iceland	839	36,606	0.784	0.770	1.08 (0.96, 1.22)	0.19
Denver	192	856	0.805	0.790	1.09 (0.83, 1.44)	0.53
Spain	351	1,195	0.819	0.764	1.40 (1.13, 1.72)	0.0019
Netherlands	515	769	0.828	0.809	1.13 (0.92, 1.39)	0.23
IARC^a	2,506	1,914	0.763	0.778	1.10 (0.99, 1.22)	0.072
Combined	4,403	41,340	-	-	1.12 (1.05, 1.20)	0.00060
rs215614-G, chromosome 7p14
Iceland	839	36,606	0.366	0.355	1.05 (0.95, 1.16)	0.37
Denver	195	864	0.403	0.376	1.12 (0.89, 1.40)	0.33
Spain	450	1,281	0.370	0.335	1.17 (1.00, 1.37)	0.055
Netherlands	502	1,709	0.366	0.367	0.99 (0.86, 1.15)	0.92
IARC^a	2,513	1,917	0.344	0.365	1.09 (1.00, 1.19)	0.057
Combined	4,499	42,377	-	-	1.07 (1.02, 1.13)	0.011
rs7937-T, chromosome 19q13
Iceland	836	36,552	0.555	0.549	1.03 (0.93, 1.13)	0.60
Denver	193	864	0.567	0.595	0.89 (0.71, 1.12)	0.32
Spain	453	1,330	0.532	0.512	1.08 (0.93, 1.26)	0.31
Netherlands	528	1,629	0.552	0.548	1.02 (0.89, 1.17)	0.80
IARC	2,518	1,921	0.559	0.580	1.09 (1.00, 1.18)	0.048
Combined	4,528	42,296	-	-	1.05 (0.99, 1.10)	0.080
rs4105144-C, chromosome 19q13
Iceland	839	36,606	0.713	0.705	1.04 (0.90, 1.20)	0.61
Denver	193	848	0.725	0.688	1.20 (0.94, 1.53)	0.14
Spain	437	1,288	0.669	0.620	1.24 (1.06, 1.46)	0.0085
Netherlands	513	1,665	0.638	0.640	0.99 (0.86, 1.15)	0.93
Combined	1,982	40,407	-	-	1.09 (1.00, 1.18)	0.040
rs7260329-G, chromosome 19q13
Iceland	831	36,454	0.688	0.669	1.09 (0.98, 1.21)	0.11
Denver	189	808	0.728	0.694	1.18 (0.92, 1.51)	0.20
Spain	457	1,305	0.702	0.674	1.14 (0.97, 1.35)	0.11
Netherlands	519	1,660	0.701	0.678	1.12 (0.96, 1.30)	0.15
IARC	2,481	1,899	0.662	0.670	1.02 (0.95, 1.10)	0.61
Combined	4,477	42,126	-	-	1.06 (1.00, 1.12)	0.041

For IARC, results for rs6474412 and rs215614 were not available and here we report results for rs6474414 and rs215605, respectively, both of which are perfect surrogates in the HapMap CEU samples (r²=1).