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Simulated median efavirenz steady-state AUC with and without concomitant rifampicin grouped according to bodyweight and CYP2B6 phenotype. The open bars are the median efavirenz steady-state AUC without concomitant rifampicin. The shaded bars are the median efavirenz steady-state AUC when co-administered with rifampicin. Abbreviations: EFV, efavirenz; EM, extensive CYP2B6 metabolizers; SM, slow CYP2B6 metabolizers
