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Simcyp™-estimated mean contribution of cytochrome P450 and UGT enzymes to single-dosed and steady-state efavirenz (EFZ) CL/F in extensive (EM) and slow (SM) CYP2B6 metabolizers
| Single dose | Steady state | |||
|---|---|---|---|---|
| EFZ (%) | EFZ (%) | |||
| Enzyme | SM | EM | SM | EM |
| CYP1A2 | 45.0 | 31.4 | 21.4 | 10.9 |
| CYP2B6 | 23.0 | 45.9 | 45.9 | 72.6 |
| CYP3A4 | 11.1 | 7.60 | 21.1 | 11.6 |
| CYP3A5 | 6.80 | 4.97 | 3.37 | 1.85 |
| CYP2A6 | 13.8 | 9.79 | 6.7.1 | 3.53 |
| UGT2B7 | 0.34 | 0.23 | 0.14 | 0.07 |
