Figure 3.

A) Boxes represent median level and the 25th and 75th percentiles, n number of patients without/with hepatotoxicity, P value of the statistical test are indicated for each cycle. B) Boxes represent median level and the 25th and 75th percentiles and bars include data between the 5^th and 95^th percentiles. This graph represents the dispersion of mean 6-MMPN concentrations in RBC for each patient depending on the occurrence of hepatotoxicities The black line indicates the threshold of RBC 6-MMPN concentrations at 5000 pmol/8 × 10⁸ RBC. C) Specificity and sensibility curves of ROC analysis. Hepatotoxicity (); No hepatotoxicity ()