Table 1.
Changes in Neural Synchrony in Adolescence and Schizophrenia
Measure | Change During Adolescence | Effect in Schizophrenia |
Resting-state oscillations | Reduction in the amplitude of delta and theta oscillations, while alpha oscillations increase. In addition, increased coherence in the alpha and beta band is observed. | Consistent support for increased delta and theta oscillations as well as for reduced alpha-band power. There is evidence for reduced coherence of resting-state oscillations. |
Steady-state responses | Increases in the amplitude and peak frequency of auditory SSRs to stimulation at 40 Hz. | Robust reductions in both the amplitude and the phase locking of 40-Hz auditory SSRs. |
Evoked oscillations | Increased phase locking of evoked alpha- and gamma-band oscillations during adolescence, possibly accompanied by reductions in the power of evoked oscillations. | Consistent evidence for deficits in phase locking of evoked oscillations in the alpha and gamma bands. |
Conflicting evidence in regard to abnormalities in the power of evoked oscillations. | ||
Induced oscillations | Pronounced increases in power of induced theta- and gamma-band oscillations. These changes are characterized by increases in long-distance synchronization at low (delta, theta) and high (beta/gamma) frequencies. | Pronounced impairments in beta- and gamma-band phase synchrony as well as reduced theta- and gamma-band power. |