Table 2.
Correlation between glucose transporter 1 expression and clinicopathologic factors in colorectal adenocarcinomas (n = 515) n (%)
| Factors | n |
Expression of GLUT1 |
||
| < 50% (%) | ≥ 50% (%) | P value | ||
| (n = 328) | (n = 187) | |||
| Age (yr) | 0.0691 | |||
| < 58 | 244 | 164 (67.2) | 80 (32.8) | |
| ≥ 58 | 271 | 164 (60.5) | 107 (39.5) | |
| Gender | 0.0091 | |||
| Male | 293 | 200 (68.3) | 93 (31.7) | |
| Female | 222 | 128 (57.7) | 94 (42.3) | |
| Tumor location | 0.5061 | |||
| Colon | 266 | 169 (63.5) | 97 (36.5) | |
| Rectum | 249 | 159 (63.9) | 90 (36.1) | |
| Tumor size (cm) | 0.5071 | |||
| < 5.7 | 282 | 180 (63.8) | 102 (36.2) | |
| ≥ 5.7 | 233 | 148 (63.5) | 85 (36.5) | |
| Tumor gross | 0.2161 | |||
| Fungating | 239 | 157 (65.7) | 82 (34.3) | |
| Infiltrative | 276 | 171 (62.0) | 105 (38.0) | |
| Tumor type | 0.0451 | |||
| Non-mucinous | 489 | 307 (62.8) | 182 (37.2) | |
| Mucinous | 26 | 21 (80.8) | 5 (19.2) | |
| Differentiation | 0.0012 | |||
| Well | 21 | 19 (90.5) | 2 (9.5) | |
| Moderate | 386 | 252 (65.3) | 134 (34.7) | |
| Poor | 108 | 57 (52.8) | 51 (47.2) | |
| T category | 0.2262 | |||
| Tis, T1 | 16 | 13 (81.3) | 3 (18.8) | |
| T2 | 35 | 22 (62.9) | 13 (37.1) | |
| T3 | 452 | 286 (63.3) | 166 (36.7) | |
| T4 | 12 | 7 (58.3) | 5 (41.7) | |
| N category | < 0.0012 | |||
| N0 | 226 | 170 (75.2) | 56 (24.8) | |
| N1 | 130 | 73 (56.2) | 57 (43.8) | |
| N2 | 159 | 85 (53.5) | 74 (46.5) | |
| M category | 0.1451 | |||
| M0 | 495 | 318 (64.2) | 177 (35.8) | |
| M1 | 20 | 10 (50.0) | 10 (50.0) | |
| AJCC stage | < 0.0012 | |||
| 0, I | 41 | 30 (73.2) | 11 (26.8) | |
| IIA, IIB | 183 | 139 (76.0) | 44 (24.0) | |
| IIIA, IIIB, IIIC | 271 | 149 (55.0) | 122 (45.0) | |
| IV | 20 | 10 (50.0) | 10 (50.0) | |
| Dukes stage | < 0.0012 | |||
| A | 12 | 10 (83.3) | 2 (16.7) | |
| B1, B2 | 208 | 156 (75.0) | 52 (25.0) | |
| C1, C2 | 275 | 152 (55.3) | 123 (44.7) | |
| D | 20 | 10 (50.0) | 10 (50.0) | |
| Apaf-1 | 0.001 | |||
| Negative | 401 | 241 (60.1) | 160 (39.9) | |
| Positive | 114 | 87 (76.3) | 27 (23.7) | |
1
Fisher’s exact test,
2
: χ2 test for linear trend. GLUT1: Glucose transporter 1; Apaf-1: Apoptosis-activating factor-1.