Figure 7.

Hypothesized Mi-2/NuRD and DICER silencing. The Mi-2/NuRD complex is possibly enriched in the H3K9me3, heat shock factor-1, and heterochromatin protein-1 regions. RNA molecules are hypothesized to contribute to the structure of the CT and PCT regions. In human cells, all dsRNAs encoded by the PCT regions are hypothetically generated by inhibitory RNA machinery (Dicer, RITS, and RDRC). In humans, CT regions are made of a repetition of AT-rich alpha satellite motifs. The size and structure of the PCT regions are made up of satellite repeats. Such regions might be preferred by stemness factors. Adapted with permission from The International Journal of Developmental Biology (Int. J. Dev. Biol.) 2009;53:259–268.