Table 2.

ML applications in single particle 3D analysis

Reference	Sample	Heterogeneity type
(Recuero-Checa et al., 2009)a	DNA ligase IV-Xrcc4	data cleaning
(Wang et al., 2009)b	RISC loading complex	substoichiometric complex
(Nickell et al., 2009)c	26S proteasome	substoichiometric complex
(Klinge et al., 2009)d	DNA polymerase α	flexible arm
(Greig et al., 2009)e	Colicin Ia	unclear
(Julian et al., 2008)	Hybrid state 70S Ribosome	ratcheting and ligand occupation
(Rehmann et al., 2008)f	EPAC2:cAMP:RAP1B	data cleaning
(Cuellar et al., 2008)	CCT:Hsc70NBD	substoichiometric complex
(Cheng et al., 2010)	Stalled 70S Ribosome	ligand occupation

^aDNA Repair 8, 1380–1389.

^bNat. Struct. Mol. Biol. 16, 1148–1153.

^cProc. Natl. Acad. Sci. U.S.A. 106, 11943–11947.

^dEMBO J. 28, 1978–1987.

^eJ. Biol. Chem. 284, 16126–16134.

^fNature 455, 124–127.