Fig. 1.

miRNA regulation of CNS myelination. Specific miRNAs involved in regulating various stages of OL differentiation and myelination are shown (or miRNAs in general in the neural precursor to OPC transition). Targets of miRNAs are shown, with confirmed targets shown in bold and predicted targets in plain text. miR-19b is expressed in both OPCs and OLs, miR-9 is more highly expressed in OPCs, and all other miRNAs shown are more highly expressed in OLs. Inhibition of expression/stage transition is shown by lines with bars, activation of expression/stage transition is shown by lines with arrows, and expression that may be detrimental to cell health/function is shown by lines with circles.