Table 3.
Tahyna virus is highly infectious and neurovirulent for weanling Swiss Webster mice, but strains differ in neuroinvasiveness
| Neuroinvasivenessa (log10PFU) | Neurovirulenceb (log10PFU) | Phenotypee | ||||
|---|---|---|---|---|---|---|
| Virus | LD50c | ID50d | LD50 | ID50 | Neuroinvasive | Neurovirulent |
| TAHV/58/CZ | 3.5 | 3.5 | 0.5 | 0.5 | Low | High |
| TAHV/58/CZ-cl(1) | 1.5 | 1.4 | 0.7 | 0.7 | High | High |
| TAHV/58/CZ-cl(2) | >5 | 4.5 | 0.8 | 0.8 | Low | High |
| TAHV/68/FR | >5 | 4.4 | 0.7 | 0.7 | Low | High |
| TAHV/68/FR-cl | >5 | 2.6 | 0.9 | 0.9 | Low | High |
| TAHV/84/CZ | >5 | 4.6 | 1.1 | 1.1 | Low | High |
| TAHV/84/CZ-cl | >5 | 3.5 | 0.3 | 0.3 | Low | High |
a Groups of weanling Swiss Webster mice (21-23 days old) were inoculated intraperitoneally with 100 μL of diluted virus (0 - 5 log10 PFU).
b Groups of weanling Swiss Webster mice (21-23 days old) were inoculated intracerebrally with 10 μL of diluted virus (1 - 4 log10 PFU).
c LD50 = Lethal dose 50%.
d ID50 = Infectious dose 50%.
e Neuroinvasive phenotype: Low = LD50 ≥ 3.5 log10 PFU; High = LD50 ≤ 1.5 log10 PFU. Neurovirulent phenotype: High = LD50 < 1.5 log10 PFU.