Table 7.
TAHV is antigenically distinct from LACV and JCV by cross neutralizing antibody assay
| Immunizing virusa | Serum neutralizing antibody titer against indicated virusb | |||
|---|---|---|---|---|
| Monkey # | LACV/78/NC-cl | JCV/61/CO-cl | TAHV/58/CZ-cl | |
| LACV/78/NC-cl | DB70 | 2077 | <10 | 383 |
| DB8N | 222 | <10 | <10 | |
| CK74 | 2782 | <10 | 80 | |
| CL2G | 326 | <10 | <10 | |
| DBCZ | 4728 | <10 | 169 | |
| CL6E | 3719 | <10 | <10 | |
| DB0H | 364 | <10 | <10 | |
| DA9F | 1374 | <10 | 82 | |
| GMTc: | 1177 | <10 | 36 | |
| JCV/61/CO-cl | A5E054 | 77 | 457 | <10 |
| A5E060 | 2825 | 352 | 282 | |
| A5E068 | 106 | 221 | 50 | |
| A5E069 | 85 | 712 | 168 | |
| A5E070 | 192 | 662 | 27 | |
| A5E073 | 140 | 256 | 49 | |
| A5E077 | 243 | 685 | 106 | |
| DBXG | 107 | 407 | 163 | |
| GMT: | 185 | 431 | 69 | |
| TAHV/58/CZ-cl | DBPN | 92 | 14 | 1698 |
| DBM6 | 58 | <10 | 494 | |
| A5E006 | 15 | <10 | 360 | |
| DBXJ | 339 | 31 | 3195 | |
| A5E036 | 113 | <10 | 316 | |
| L27 | 15 | <10 | 215 | |
| DC11 | 151 | <10 | 1613 | |
| GMT: | 68 | 11 | 725 | |
a Monkeys were immunized subcutaneously with 5 log10 PFU of indicated virus and serum was collected on day 28.
b Reciprocal PRNT60 assayed against indicated virus. Lower limit of detection is 10.
b Geometric mean titer. For the purpose of calculation, a value of 9 was assigned to monkeys with titers less than 10.