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. 2011 Apr 21;7(4):e1001368. doi: 10.1371/journal.pgen.1001368

Figure 2. MCMV resistance in FVB/N×BALB.K F2 progeny dependent on specific combinations between the NKC and H2.

Figure 2

(A) Genetic analysis of MCMV infection control in FVB/N×BALB.K F2 progeny. Mice (FVB/N and BALB.K, n = 11 per strain; FVB/N×BALB.K F2, n = 137) were infected with 5,000 PFU of MCMV; the spleen viral titers were determined by plaque assay at day 3 p.i. (B) Box plots show the combined effect of the NKC and H2 loci derived from FVB/N (H2qq and NKCff) or BALB.K (H2kk and NKCcc) parental mice on the viral loads in the spleens of the F2 progeny. The median and interquartile ranges are shown. Solid dots denote outliers. The red box corresponds to the combination of NKCff and H2kk loci (P<6×10−11).