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. 2011 Apr 21;7(4):e1001376. doi: 10.1371/journal.pgen.1001376

Figure 3. rDNA–responsive genes are found throughout the genome.

Figure 3

(A) Number of differentially expressed genes either up-regulated or down-regulated as a function of cytological location. Each cytological division shows grouped data for all three Y chromosomes (YrDNA-mild-1, YrDNA-mild-2, YrDNA-gross) relative to the wild-type Y chromosome (at P<0.01). (B) Distribution of microarray spots yielding high quality data (gray bars) with scanning 5-division average (gray line). Overlaid scanning 5-division average (black line) of the number of differentially expressed genes. For each window we show the number of differentially expressed genes grouped for all three chromosomes (YrDNA-mild-1, YrDNA-mild-2, and YrDNA-gross) relative to the wild-type Y chromosome (P<0.01). (C) Scanning 5-division average of number of differentially expressed genes only from males (black) and females (gray) bearing YrDNA-gross (at P<0.01). Cytological divisions are aligned across entire figure (dotted vertical lines). Stylized chromosome map represents euchromatic regions of the genome and location of centromeres and centric heterochromatin (ovals).