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. 2011 Apr 21;6(4):e18635. doi: 10.1371/journal.pone.0018635

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Peleg et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Experiments done in MEF cells which are stimulated by PDGF. (A) Time-lapse of CDRs dynamics. Still images of MEF cells serum-starved and pre-treated with vehicle (upper panels) or Blebbistatin (lower panels) and subsequently treated with PDGF to induce CDRs formation. CDR dynamics were recorded by time-lapse video microscopy (see also Movie S1 and Methods section). Bar, 20 m. (B) The fraction of cells exhibiting CDRs is unaffected by treatment with two different myosin II inhibitors. P-values show no statistical significance. (C) IRSp53 is localized at CDRs. IRSp53 marked in green and actin in red. Bar 10 . Arrows denotes CDRs.

Inline graphic — Experiments done in MEF cells which are stimulated by PDGF. (A) Time-lapse of CDRs dynamics. Still images of MEF cells serum-starved and pre-treated with vehicle (upper panels) or Blebbistatin (lower panels) and subsequently treated with PDGF to induce CDRs formation. CDR dynamics were recorded by time-lapse video microscopy (see also Movie S1 and Methods section). Bar, 20 m. (B) The fraction of cells exhibiting CDRs is unaffected by treatment with two different myosin II inhibitors. P-values show no statistical significance. (C) IRSp53 is localized at CDRs. IRSp53 marked in green and actin in red. Bar 10 . Arrows denotes CDRs.