Figure 3.

Nitric oxide [NO] donor dipropylenetriamine NONOate (DPTA-NO) treatment prevents vasoconstriction and attenuates the decrease in red blood cell (RBC) velocities in pial vessels during Plasmodium berghei ANKA (PbA) infection. Changes in arteriolar and venular diameters (A, B) and RBC velocities (C, D) in uninfected controls, and saline-treated and DPTA-NO-treated PbA-infected mice during PbA infection. Number of vessels analyzed: uninfected controls: 36 arterioles and 66 venules; saline-treated: 42 arterioles and 56 venules; DPTA-NO–treated: 51 arterioles and 128 venules. *: P < .05 compared with controls; #: P < .05 compared with DPTA-NO. Statistical analysis was performed by 2-way analysis of variance (ANOVA) for nonparametric repeated measurements, and post hoc analyses were performed using Bonferroni test. Data are from 3 experiments.