Table 4.
Effect of Aggregated IgG and Goat F(ab')2 Anti-IgG Fc Antibody on Virus Titers in Secondary DENV Infection
| Serum ID no. | Cell Line | Treatment | Virus Titer (log10 PFU/mL) | P-valuea (BHK) | P-valueb (FcγR-BHK) |
| S4 | FcγR-BHK | None | 7.90 ± 0.15 | .032 | c |
| BHK | None | 6.69 ± 0.12 | - | .032 | |
| FcγR-BHK | Aggregated IgG | 6.78 ± 0.49 | .415 | .034 | |
| FcγR-BHK | F(ab')2 anti-IgG Fc antibody | 6.87 ± 0.04 | .077 | .033 | |
| S9 | FcγR-BHK | None | 7.34 ± 0.05 | .012 | - |
| BHK | None | 6.60 ± 0.34 | - | .012 | |
| FcγR-BHK | Aggregated IgG | 6.77 ± 0.21 | .276 | .015 | |
| FcγR-BHK | F(ab')2 anti-IgG Fc antibody | 6.70 ± 0.12 | .349 | .008 |
NOTE. aP-value of virus titer compared with those determined using BHK cells in the absence of any treatment.
b
P-value of virus titer compared with those determined using FcγR-expressing BHK cells in the absence of any treatment.
c
- Indicates that calculation is not possible.