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. 2011 Apr 21;6(4):e19090. doi: 10.1371/journal.pone.0019090

Table 1. List of germline and tissue specific conditional ATF2 deletions.

Genotype Mutation Phenotype
Atf2−/− Germline deletion 100% lethality at birth
Atf2AA T51/T53 mutation Same as Atf2−/−
Atf2Δneuron Atf2f/f;nestin-Cre Same as Atf2−/−
Atf2Δepiblast Atf2f/f;meox2-Cre Same as Atf2−/−

Atf2 / mutant mice were obtained as a result of Atf2+/ x Atf2+/ crosses. Atf2AA were the result of Atf2+/AA x Atf2+/AA crosses. Atf2Δneuron and Atf2Δepiblast resulted from Atf2f/f x Atf2f/+;nestin-Cre and Atf2f/f x Atf2f/+;meox2-Cre crosses, respectively. All animals were on a C57/Bl6 strain background. A minimum of 10 offspring litters were analysed for each knockout combination.