Table 1. List of germline and tissue specific conditional ATF2 deletions.
Genotype | Mutation | Phenotype |
Atf2−/− | Germline deletion | 100% lethality at birth |
Atf2AA | T51/T53 mutation | Same as Atf2−/− |
Atf2Δneuron | Atf2f/f;nestin-Cre | Same as Atf2−/− |
Atf2Δepiblast | Atf2f/f;meox2-Cre | Same as Atf2−/− |
Atf2− /− mutant mice were obtained as a result of Atf2+/− x Atf2+/− crosses. Atf2AA were the result of Atf2+/AA x Atf2+/AA crosses. Atf2Δneuron and Atf2Δepiblast resulted from Atf2f/f x Atf2f/+;nestin-Cre and Atf2f/f x Atf2f/+;meox2-Cre crosses, respectively. All animals were on a C57/Bl6 strain background. A minimum of 10 offspring litters were analysed for each knockout combination.