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(A) Blood pharmacokinetics. All Aux-PEGy NPs showed revealed extended circulation times in blood. (B) Organ-level biodistribution. Bulk particle localization in the liver, spleen, and kidney was size-dependent. Gold contents are normalized to percent injected dose (% ID). For all particle sizes, the five named organs plus the blood compartment accounted for at least 70% ID of the injected dose. Error bars indicate 1 SD from each Aux-PEGy NP class (n = 3).
