Fig. 6.

RGM-A fails to attenuate ZyA-induced peritonitis in neo1^−/− mice. After neo1^−/− mice were injected i.p. with 1 mg of ZyA (1 mg/mL), they received i.v. recombinant murine RGM-A (1 μg in 0.2% BSA) or vehicle. (A) Cell count in peritoneal lavage obtained after 4 h. (B) MPO activity in peritoneal lavage fluid obtained after 4 h. (C) Cytokine levels of TNF-α measured by ELISA in peritoneal fluid of WT neo1^−/− mice 4 h after ZyA-induced peritonitis. (D) IL-1β, (E) IL-6, and (F) MIP-1α levels in peritoneal fluid WT compared with Neo^−/− mice.