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. 2011 Apr 4;108(16):6567–6572. doi: 10.1073/pnas.1018331108

Fig. 1.

Fig. 1.

Granulocytosis in IkkβΔ mice requires TNFR-1 and occurs in the absence of lymphocytes. WBC counts (A) and spleen weights (B) of IkkβF/F, IkkβΔ, Tnfr1−/−, and IkkβΔ/Tnfr1−/− double KO mice 21 d after poly(I:C) administration. Data are mean ± SE from at least three mice (*P < 0.05, **P < 0.01; n.s, not significant). (C) Representative FACS plots of CD11b+/Gr-1+ cells in bone marrow of IkkβF/F, IkkβΔ, Tnfr1−/−, and IkkβΔ/Tnfr1−/− double KO mice. Numbers within the plot indicate the percentage of double-positive cells. Plots are representative of at least four mice per genotype. (D and E) WBC counts (D) and spleen weights (E) of Rag1−/− and IkkβΔ/Rag1−/− compound mutants 21 d after poly(I:C) administration. Data are mean ± SE from at least three mice (*P < 0.05, ***P < 0.0001). (F) Representative FACS plots of CD11b+/Gr-1+ cells in bone marrow of Rag1−/− and IkkβΔ/Rag1−/− double KO mice. Plots are representative of five mice per genotype.