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Time course of of recombinant CHO cells grown in batch culture in a 5 L bioreactor. a: viable cell density and C12 antibody concentration (Ab); viability; specific growth rate; specific C12 antibody production rate (Qp); b: residual glucose, lactate concentration, Ycells/gluc and Ylac/gluc; c: osmolality, glutamine, ammonia and alanine concentration; d: amino acid concentration
