Fig. 4.
Proposed classification of GB viruses. GBV-B, a member of the genus Hepacivirus with type species HCV, would be renamed GB virus (GBV); this virus is the true GB agent causing acute hepatitis in experimentally infected tamarins. The new genus designation for GBV-A, GBV-C/HGV and GBV-D would be Pegivirus for persistent ‘GB’ or ‘G’ virus. GBV-A and GBV-A-like viruses would become simian Pegivirus (SPgV) and species-specific viruses would have the species name in subscripts. GBV-C (or HGV) would become the human Pegivirus (HPgV), GBV-Ccpz would become SPgVcpz, and GBV-D would become bat Pegivirus (BPgV). If BPgV isolates found in different bat species segregate by species as with SPgV, the host species will be identified as a subscript. Examples of other viruses within the family Flaviviridae are shown for comparison.