Figure 2.

Averaged results (mean ± SEM) from the animals in group I-a (N = 6), which received adenosine and ferumoxytol. The upper graph shows mean R₂ values in the cortex, OSOM and ISOM over the course of the experiment. Adenosine infusion was switched on and off between successive acquisitions, both prior to ferumoxytol administration (acquisitions 1 – 3) and after ferumoxytol administration (acquisitions 4 – 8). The lower graph shows the area of the kidney, normalized to its value in acquisition 1, and averaged over all animals. The results for acquisition 6 – 8 were averaged over only 5 animals, since one rat was withdrawn from the scanner after acquisition 5 due to respiratory distress. As in Figure 1, R₂ increases with ferumoxytol administration (acquisition 4) and increases further with adenosine (5 and 7). Adenosine also produces a slight increase in R₂ in the absence of ferumoxytol (acquisition 2) and causes a reduction in the cross-sectional area of the kidney (acquisitions 2, 5 and 7).